FlexGUI first attempt - basic layout?

Just getting started with Flex; I've never really done a GUI from scratch so I haven't internalized any 'best practices' or anything.

Goal is something like below.  I started fiddling last night but quickly realized I needed some experienced advice on how to organize & lay-out this thing.

Details aren't set in stone now, but I want a GUI with no on-screen controls/jogging on the main page.  Will be used with 15.6" touchscreen 1920x1080p monitor - so I can't cram lots of small stuff in.

Maybe something like:

• Main window
  • Horizontal layout
    • Frame (variable displays top)
      • Vertical layout
        • Stacked widget (left)
        • Frame for stacked widget buttons (right)
    • Frame (fixed displays middle)
      • Vertical layout
        • Frames across for each 'section'
    • Frame (fixed indicators btm)
      • Vertical layout
        • indicators + estop/on btns

Or is there a better way of laying this out that doesn't wind up with me painting myself in to a corner?  I don't like tabs, so no tabbed widgets.

Thx