May I ask, why would you need 500V OVP? Pick a plasma and I dare you to find one with an open circuit voltage (OCV) over 400V, this would be the voltage without current flowing. No plasma in the cutting business will sustain a 400V arc length with a current capable of cutting metal. Plasma's used to cut metal, will typically not go much beyond 200V and the powermax type of stuff 150V (these are rough numbers). Then lets say you divide it by 20 (the lower one of your dividers) that's 20V.
Mesa that is connected directly to the raw arc voltage tolerating 500V is something that makes sense, my guess the 500V withstand voltage is the resistor max rating. Note this is not OVP, its what the pcb will withstand "forever".
Then if you are thinking about example beckhoff EL3064, it has an electrical isolation of 500V, but that's from the ADC to "LAN". I can't find a definitive max input voltage but i assume its the "Dielectric strength" of 30V, I find that to be weird terminology.
There is no point to over engineer this stuff. You can have safety margins, and you should, but reading an analog voltage that normally ranges from 0-5V, or even 0-10V, does not need to withstand x 10.