Is it possible to use Python to customize all interface?

Hi,everyone ,I'm going to build a machine with lathe and 4 axis milling function,and to the software developing part ,after reading the official doc of the linuxcnc .it looks that the linuxcnc could be used as a python module.So I'm going to use Python with Tkinter to bulid the GUI interface,and use the linuxcnc python module to control the machine,that's only a plan ,but I dont know if it can be really workable ? Has anyone done this like before ,welcome any advices or comments.Thanks

Thank you ,and I think the pure tkinter is too old-fasioned ,I 'd like to import some third part open-source lib such as CustomerTkinter, that looks better .

If it does not have to be tkinter maybe check also kivy?